Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer with β-cyclodextrin-modified hollow mesoporous silica nanoparticles for controlled drug release.

نویسندگان

  • Xiao Mei
  • Shun Yang
  • Dongyun Chen
  • Najun Li
  • Hua Li
  • Qingfeng Xu
  • Jianfeng Ge
  • Jianmei Lu
چکیده

Hollow mesoporous silica nanoparticles (HMSs) were modified by β-cyclodextrin via a "click" reaction, an amphiphilic copolymer with a trans-azobenzene structure was then assembled onto β-cyclodextrin to cover the surface of the HMSs. The prepared nanocomposites can release drugs in a "release-stop-release" manner by converting light irradiation.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A reversible light-operated nanovalve on mesoporous silica nanoparticles.

Two azobenzene α-cyclodextrin based nanovalves are designed, synthesized and assembled on mesoporous silica nanoparticles. Under aqueous conditions, the cyclodextrin cap is tightly bound to the azobenzene moiety and capable of holding back loaded cargo molecules. Upon irradiation with a near-UV light laser, trans to cis-photoisomerization of azobenzene initiates a dethreading process, which cau...

متن کامل

Amphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment.

The light-triggered controlled release of anticancer drugs accompanied with NIR-responsive photodynamic therapy was prepared via a self-assembly process. Firstly, Mn(2+)-doped upconversion nanoparticles (UCNPs) were coated with a mesoporous silica shell and modified with photosensitizer (Chlorin e6) and long alkyl chains. And then the NIR light-responsive amphiphilic copolymer containing 9,10-d...

متن کامل

NIR-triggered anticancer drug delivery by upconverting nanoparticles with integrated azobenzene-modified mesoporous silica.

Cancer is one of the most common causes of death in the world, and chemotherapy remains to be one of the most frequent treatments for many cancers. However, its success has been greatly limited because of systemic toxicity due to the toxic effects by the nonspecific distribution of anti-cancer drugs. The drug delivery systems with the features of sustained drug release have attracted much atten...

متن کامل

Folic acid-modified mesoporous silica nanoparticles for cellular and nuclear targeted drug delivery.

Site-specific stimuli responsive nanomaterials are an important breakthrough for the improvement of modern therapies in nanomedicine. Mesoporous silica nanoparticles are good candidate for the development of targeted delivery system as their surface can be easily modified with functional groups in order to achieve controlled and specific release. We designed a drug delivery system based on meso...

متن کامل

Hollow Mesoporous Silica Nanoparticles (HMSNs) Synthesis and in vitro Evaluation of Cisplatin Delivery

Cisplatin continues to be a first line chemotherapy agent alone or in combination with other cytotoxic agents orradiotherapy. Dose-limiting side effects, intrinsic and acquired resistance are the main reasons for inventing and developing new ways of delivering cisplatin. Biocompatible hollow porous materials offer high void volume, shell porosity, low density and controllable size which make th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 48 80  شماره 

صفحات  -

تاریخ انتشار 2012